Genomic Analysis of Invasive Human Bone Marrow Derived Mesenchymal Stem Cells.

ABSTRACT:

Background

Human bone marrow derived mesenchymal stem cells (hMSCs) are capable of differentiation into multiple cell lineages and demonstrate a wide variety of use in various therapeutic applications. Only recently has research begun to understand the gene expression profiles of hMSCs and their differentiated counterparts in vivo and ex vivo.

Purpose

The research presented here aimed at gaining a better understanding of gene expression patterns present during hMSC invasion through a basement membrane.

Methods

Changes in gene expression were evaluated between invasive and non-invasive cells using Agilent's gene expression arrays and Matrigel invasion chambers. The cells were specifically attracted to a defined stem cell media called SCM.

Results

A

SUBMITTER: Mathews LA 

PROVIDER: S-EPMC3999892 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature