Transcriptional profiling of the host cell response to feline immunodeficiency virus infection.

ABSTRACT:

Background

Feline immunodeficiency virus (FIV) is a widespread pathogen of the domestic cat and an important animal model for human immunodeficiency virus (HIV) research. In contrast to HIV, only limited information is available on the transcriptional host cell response to FIV infections. This study aims to identify FIV-induced gene expression changes in feline T-cells during the early phase of the infection. Illumina RNA-sequencing (RNA-seq) was used identify differentially expressed genes (DEGs) at 24 h after FIV infection.

Results

After removal of low-quality reads, the remaining sequencing data were mapped against the cat genome and the numbers of mapping reads were counted for each gene. Regulated genes were identified through the comparison of FIV and mock-infected dat

SUBMITTER: Ertl R 

PROVIDER: S-EPMC3999937 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature