Characterization of biofilm formation and the role of BCR1 in clinical isolates of Candida parapsilosis.

ABSTRACT: In Candida parapsilosis, biofilm formation is considered to be a major virulence factor. Previously, we determined the ability of 33 clinical isolates causing bloodstream infection to form biofilms and identified three distinct groups of biofilm-forming strains (negative, low, and high). Here, we establish two different biofilm structures among strains forming large amounts of biofilm in which strains with complex spider-like structures formed robust biofilms on different surface materials with increased resistance to fluconazole. Surprisingly, the transcription factor Bcr1, required for biofilm formation in Candida albicans and C. parapsilosis, has an essential role only in strains with low capacity for biofilm formation. Although BCR1 leads to the formation of more and longer pseudohypha

SUBMITTER: Pannanusorn S 

PROVIDER: S-EPMC4000102 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature