CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls.

ABSTRACT:

Background

Childhood obesity and early puberty are intermediate risk factors for later metabolic and reproductive disorders including diabetes, polycystic ovarian syndrome (PCOS), and breast cancer. Atypical methylation patterns in genes related to hormone and adipose metabolism, such as CYP19A1 (aromatase) and PPARG (peroxisome proliferator-activated receptor gamma), are associated with alterations in gene expression which may contribute to pathogenesis of these diseases. If present in early life, it is conceivable similar methylation aberrations may result in hormone perturbations that alter pubertal timing.

Methods

We used Cox proportional hazard models to investigate whether promoter methylation of CYP19A1 and PPARG, independently or in concert with body weight, was asso

SUBMITTER: Stueve TR 

PROVIDER: S-EPMC4000125 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature