Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice.

ABSTRACT:

Background

Higher brain function is supported by the precise temporal and spatial regulation of thousands of genes. The mechanisms that underlie transcriptional regulation in the brain, however, remain unclear. The Ntng1 and Ntng2 genes, encoding axonal membrane adhesion proteins netrin-G1 and netrin-G2, respectively, are paralogs that have evolved in vertebrates and are expressed in distinct neuronal subsets in a complementary manner. The characteristic expression patterns of these genes provide a part of the foundation of the cortical layer structure in mammals.

Results

We used gene-targeting techniques, bacterial artificial chromosome (BAC)-aided transgenesis techniques, and in vivo enhancer assays to examine transcriptional mechanisms in vivo to gain insight into how the

SUBMITTER: Yaguchi K 

PROVIDER: S-EPMC4000137 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature