Association between vitamin D receptor gene polymorphisms and breast cancer risk: a meta-analysis of 39 studies.

ABSTRACT:

Background

The associations between vitamin D receptor (VDR) gene polymorphisms and breast cancer risk were comprehensively investigated to clarify issues that remain controversial.

Methodology/principal findings

An electronic search was conducted of several databases, including PubMed, the Cochrane library, Web of Science, EMBASE, CBM and CNKI, for papers that describe the association between Fok1, poly-A repeat, Bsm1, Taq1 or Apa1 polymorphisms of the VDR gene and breast cancer risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effect model (FEM) or random-effect model (REM), depending on the absence or presence of significant heterogeneity. A total of 39 studies met the inclusion criteria. A meta-analysis of high-quality studies sh

SUBMITTER: Zhang K 

PROVIDER: S-EPMC4000223 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature