Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia.

ABSTRACT:

Background

Traumatic brain injury (TBI) is associated with a higher incidence of depression. The majority of individuals who suffer a TBI are juveniles and young adults, and thus, the risk of a lifetime of depressive complications is a significant concern. The etiology of increased TBI-associated depression is unclear but may be inflammatory-related with increased brain sensitivity to secondary inflammatory challenges (e.g., stressors, infection, and injury).

Methods

Adult male BALB/c mice received a sham (n = 52) or midline fluid percussion injury (TBI; n = 57). Neuroinflammation, motor coordination (rotarod), and depressive behaviors (social withdrawal, immobility in the tail suspension test, and anhedonia) were assessed 4 hours, 24 hours, 72 hours, 7 days, or 30 days late

SUBMITTER: Fenn AM 

PROVIDER: S-EPMC4000292 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature