Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures.

ABSTRACT:

Objective

Compare neurodevelopment after levetiracetam (LEV) and phenobarbital (PB) for neonatal seizures.

Study design

Retrospective study of infants who received antiepileptic drugs (AEDs) for neonatal seizures. Effect of cumulative exposure to LEV and PB on outcomes of death, cerebral palsy (CP) and Bayley Scales of Infant Development (BSID) scores were evaluated at 24 months corrected age. Analyses were adjusted for number of electrographic seizures and gestational age.

Result

In 280 infants with comparable seizure etiology and cranial imaging results, increased exposure to PB was associated with worse BSID cognitive and motor scores (8.1- and 9-point decrease per 100 mg kg(-1); P=0.01). The effect was less with LEV (2.2- and 2.6-point decrease per 300 mg kg(-1) L

SUBMITTER: Maitre NL 

PROVIDER: S-EPMC4000307 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature