Identification of genetic loci associated with primary angle-closure glaucoma in the basset hound.

ABSTRACT:

Purpose

Primary angle-closure glaucoma (PACG) in dogs is usually caused by the gradual collapse of the iridocorneal angle and cleft, eventually leading to aqueous humor (AH) outflow obstruction. The condition occurs in several breeds of dogs and the prognosis for affected animals is typically poor. We have identified several basset hound (BH) pedigrees, as well as unrelated cases with characteristic PACG that in many aspects recapitulates PACG in human patients. The goal of this study was to utilize the BH PACG model to characterize the genetics of PACG, and potentially discover genetic factors contributing to PACG in humans and animals.

Methods

We conducted a genome-wide logistic regression test for association using 37 PACG cases and 41 unaffected controls. Population stra

SUBMITTER: Ahram DF 

PROVIDER: S-EPMC4000717 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature