Regionally-specific alterations in myelin proteins in nonhuman primate white matter following prolonged cocaine self-administration.

ABSTRACT:

Background

Neuroimaging studies of cocaine users have demonstrated white matter abnormalities associated with behavioral measures of impulsivity and decision-making deficits. The underlying bases for this dysregulation in white matter structure and function have yet to be determined. The aim of the present studies was to investigate the influence of prolonged cocaine self-administration on the levels of myelin-associated proteins and mRNAs in nonhuman primate white matter.

Methods

Rhesus monkeys (N=4) self-administered cocaine (0.3mg/kg/inj, 30 reinforcers per session) for 300 sessions. Control animals (N=4) responded for food. Following the final session monkeys were euthanized and white matter tissue at three brain levels was processed for immunoblotting analysis of proteo

SUBMITTER: Smith HR 

PROVIDER: S-EPMC4000724 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature