The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders.

ABSTRACT: As with most bioavailable transition metals, iron is essential for many metabolic processes required by the cell but when left unregulated is implicated as a potent source of reactive oxygen species. It is uncertain whether the brain's evident vulnerability to reactive species-induced oxidative stress is caused by a reduced capability in cellular response or an increased metabolic activity. Either way, dys-regulated iron levels appear to be involved in oxidative stress provoked neurodegeneration. As in peripheral iron management, cells within the central nervous system tightly regulate iron homeostasis via responsive expression of select proteins required for iron flux, transport and storage. Recently proteins directly implicated in the most prevalent neurodegenerative diseases, such as am

SUBMITTER: Wong BX 

PROVIDER: S-EPMC4001010 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature