Association between TLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users.

ABSTRACT:

Background

TLR3 recognizes dsRNA and triggers immune responses against RNA and DNA viruses. A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection. We investigated Caucasian intravenous drug users (IDUs) and blood donors in order to evaluate the associations between TLR3 genotypes and susceptibility to HIV infection.

Materials and methods

A total of 345 Caucasian IDUs were recruited, 50% of them were HIV positive, 89% HCV and 77% HBV positive. Based on their history of needle sharing, 20 of the HIV negative IDUs were classified as highly exposed HIV seronegatives (HESNs), 68 as non-HESNs and 85 as unexposed. The control group consisti

SUBMITTER: Huik K 

PROVIDER: S-EPMC4001117 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature