Effect of immediate and delayed high-strain loading on tendon-to-bone healing after anterior cruciate ligament reconstruction.

ABSTRACT:

Background

We previously demonstrated, in a rat anterior cruciate ligament (ACL) graft reconstruction model, that the delayed application of low-magnitude-strain loading resulted in improved tendon-to-bone healing compared with that observed after immediate loading and after prolonged immobilization. The purpose of this study was to determine the effect of higher levels of strain loading on tendon-to-bone healing.

Methods

ACL reconstruction was carried out in a rat model in three randomly assigned groups: high-strain daily loading beginning on either (1) postoperative day one (immediate-loading group; n = 7) or (2) postoperative day four (delayed-loading group; n = 11) or (3) after prolonged immobilization (immobilized group; n = 8). Animals were killed two weeks after surge

SUBMITTER: Packer JD 

PROVIDER: S-EPMC4001459 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature