Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling.

ABSTRACT: Nuclear factor-kappa B (NF-κB) transcription factors regulate cellular processes such as inflammation and cell survival. The NF-κB pathway is often activated with development and progression of head and neck squamous cell carcinoma (HNSCC). As such, NF-κB represents an attractive target for chemoprevention. HNSCC involves progression of lesions from premalignant to malignant, providing a window of opportunity for intervention with chemopreventive agents. Appropriate chemopreventive agents should be inexpensive, nontoxic, and target important pathways involved in the development of HNSCC. Several such agents that inhibit the NF-κB pathway have been investigated in HNSCC. Retinoids have been studied most extensively but have shown limited potential in human trials. Epidermal growth factor re

SUBMITTER: Vander Broek R 

PROVIDER: S-EPMC4002662 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature