Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population.

ABSTRACT:

Aim

To investigate the association of polymorphisms in four critical genes implicated in the NO-forming pathway with ischemic stroke (IS) in a Chinese Han population.

Methods

DNA samples of 558 IS patients and 557 healthy controls from Chinese Han population were genotyped using the Taqman(TM) 7900HT Sequence Detection System. Six SNPs (rs841, rs1049255, rs2297518, rs1799983, rs2020744, rs4673) of the 4 related genes (eNOS, iNOS, GCH1, and CYBA) in the NO forming pathway were analyzed using the SPSS 13.0 software package for Windows.

Results

One SNP located in the intron of GCH1 (rs841) was associated with IS independent of the traditional cardiovascular risk factors in co-dominant and dominant models (P=0.003, q=0.027; P=0.00006, q=0.0108; respectively). Moreover, th

SUBMITTER: Yan JT 

PROVIDER: S-EPMC4002730 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature