Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China.

ABSTRACT:

Aim

SOCS3 gene plays an important role in the pathogenesis of obesity in animal models, but the data from human studies are relatively limited. To address this issue, a genetic association analysis on nationalities with different genetic background living in the similar environmental conditions was performed.

Methods

Two thousand seven hundred eleven subjects were randomly recruited from the Kazakh, Uygur and Han nationalities in Xinjiang of China. SNP polymorphisms rs4969168 and rs9892622 within or near the SOCS3 gene were genotyped using TaqMan-MGB™ assay. Association study between the two polymorphisms and obesity-related traits (body mass index [BMI]; waist-to-hip ratio [WHR]; weight; height, waist, and hip measurements) was conducted.

Results

Significant associat

SUBMITTER: Tang W 

PROVIDER: S-EPMC4002737 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature