End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.

ABSTRACT:

Objective

Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that exhibits familial aggregation and may progress to end-stage renal disease (ESRD). LN is more prevalent among African Americans than among European Americans. This study was undertaken to investigate the hypothesis that the apolipoprotein L1 gene (APOL1) nephropathy risk alleles G1/G2, common in African Americans and rare in European Americans, contribute to the ethnic disparity in risk.

Methods

APOL1 G1 and G2 nephropathy alleles were genotyped in 855 African American SLE patients with LN-ESRD (cases) and 534 African American SLE patients without nephropathy (controls) and tested for association under a recessive genetic model, by logistic regression.

Results

Ninety per

SUBMITTER: Freedman BI 

PROVIDER: S-EPMC4002759 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature