FGFR4 genetic polymorphisms determine the chemotherapy response of Chinese patients with non-small cell lung cancer.

ABSTRACT:

Aim

To investigate the relationship of fibroblast growth factor receptor 4 (FGFR4) gene polymorphisms with the response of Chinese patients with non-small cell lung cancer (NSCLC) to chemotherapy.

Methods

A total of 629 patients with Stage III (A+B) or IV NSCLC, as well as 729 age- and gender-matched healthy controls were recruited. All the patients received platinum-based chemotherapy, and the therapeutic effects were evaluated. Three polymorphisms in the FGFR4 gene (rs351855G/A, rs145302848C/G, and rs147603016G/A) were genotyped, and the association between the 3 polymorphisms and the chemotherapy effect was analyzed using SPSS software, version 16.0.

Results

The genotype frequencies of rs145302848C/G and rs147603016G/A were not significantly different between NSCLC

SUBMITTER: Fang HM 

PROVIDER: S-EPMC4002793 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature