Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males.

ABSTRACT:

Aim

PRD1-BF-1-RIZ1 homologous domain containing protein-16 (PRDM16) is a cell-autonomous transcriptional component that stimulates the development of brown fat cells. The aim of this study was to investigate the contribution of genetic variants of PRDM16 to obesity-related phenotype variations in Chinese.

Methods

A total of 3204 subjects (consisting of 400 male-offspring nuclear families, 401 female-offspring nuclear families, and 729 unrelated older males) were recruited. Ten tag single nucleotide polymorphisms (SNPs) within the PRDM16 gene were genotyped using multiplex quantitative real-time PCR by Taqman assay. Body compositions were measured by dual-energy X-ray absorptiometry (DXA). The associations of the SNPs with the obesity-related phenotypes were analyzed using th

SUBMITTER: Yue H 

PROVIDER: S-EPMC4002873 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature