A composite outcome for neonatal cardiac surgery research.

ABSTRACT:

Objective

The objective of this study was to determine whether a composite outcome, derived of objective signs of inadequate cardiac output, would be associated with other important measures of outcomes and therefore be an appropriate end point for clinical trials in neonatal cardiac surgery.

Methods

Neonates (n = 76) undergoing cardiac operations requiring cardiopulmonary bypass were prospectively enrolled. Patients were defined to have met the composite outcome if they had any of the following events before hospital discharge: death, the use of mechanical circulatory support, cardiac arrest requiring chest compressions, hepatic injury (2 times the upper limit of normal for aspartate aminotransferase or alanine aminotransferase), renal injury (creatinine >1.5 mg/dL), or lac

SUBMITTER: Butts RJ 

PROVIDER: S-EPMC4004075 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature