Ontology highlight
ABSTRACT:
SUBMITTER: Winter SE
PROVIDER: S-EPMC4004111 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130201 6120
Changes in the microbial community structure are observed in individuals with intestinal inflammatory disorders. These changes are often characterized by a depletion of obligate anaerobic bacteria, whereas the relative abundance of facultative anaerobic Enterobacteriaceae increases. The mechanisms by which the host response shapes the microbial community structure, however, remain unknown. We show that nitrate generated as a by-product of the inflammatory response conferred a growth advantage to ...[more]