Biosynthesis of a thiamin antivitamin in Clostridium botulinum.

ABSTRACT: Bacimethrin-derived 2'-methoxythiamin pyrophosphate inhibits microbial growth by disrupting metabolic pathways dependent on thiamin-utilizing enzymes. This study describes the discovery of the bacimethrin biosynthetic gene cluster of Clostridium botulinum A ATCC 19397 and in vitro reconstitution of bacimethrin biosynthesis from cytidine 5'-monophosphate.

SUBMITTER: Cooper LE 

PROVIDER: S-EPMC4004229 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature