Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria.

ABSTRACT:

Background

Cytoadhesion of Plasmodium falciparum-infected erythrocytes to endothelial cells in microvessels is a remarkable characteristic of severe malaria. The endothelial protein C receptor (EPCR), encoded by the endothelial protein C receptor gene (PROCR), has recently been identified as an endothelial receptor for specific P. falciparum erythrocyte membrane protein 1 (PfEMP1) subtypes containing domain cassettes (DCs) 8 and 13. The PROCR rs867186-G allele (serine-to-glycine substitution at position 219 of EPCR; 219Gly) has been shown to be associated with higher levels of plasma soluble EPCR (sEPCR). In this study, the association of PROCR rs867186 with severe malaria is examined in Thai population.

Methods

A total of 707 Thai patients with P. falciparum malaria (341 wi

SUBMITTER: Naka I 

PROVIDER: S-EPMC4004250 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature