Oxacycle synthesis via intramolecular reaction of carbanions and peroxides.

ABSTRACT: The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C-C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.

SUBMITTER: Willand-Charnley R 

PROVIDER: S-EPMC4004269 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature