Genetic variations in regulator of G-protein signaling (RGS) confer risk of bladder cancer.

ABSTRACT:

Background

Alterations in the regulator of G-protein signaling (RGS) pathway have been implicated in several cancers; therefore, the authors investigated the role of such alterations in overall bladder cancer risk, recurrence, progression, and survival.

Methods

In this case-control series, 803 patients with bladder cancer were frequency-matched with a control cohort of 803 healthy individuals. Ninety-five single-nucleotide polymorphisms (SNPs) in 17 RGS genes were investigated for an association with overall bladder cancer risk, recurrence, and progression in patients who had nonmuscle-invasive bladder cancer (NMIBC) and for an association with death in patients who had muscle-invasive bladder cancer (MIBC). Cumulative effects and classification and regression tree analyses

SUBMITTER: Lee EK 

PROVIDER: S-EPMC4004376 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature