Indirect comparison analysis of efficacy and safety between olanzapine and aripiprazole for schizophrenia.

ABSTRACT:

Aims

Indirect comparison (IC) and direct comparison (DC) between aripiprazole and olanzapine for schizophrenia were conducted to compare their efficacy and safety. The objective was to determine the usability of IC and consistency of results delivered by the two comparisons. Factors that might influence the inconsistency of results were also investigated.

Methods

ICs and DCs were conducted using the change from baseline of the Positive and Negative Syndrome Scale (PANSS) total score as an efficacy endpoint and the dropout rate was selected as a safety endpoint. Placebo and risperidone were used as common comparators for ICs.

Results

A literature search identified 20 articles. The efficacy analysis gave results on the mean difference in PANSS change (95% CI) of -5.72 (

SUBMITTER: Kunitomi T 

PROVIDER: S-EPMC4004397 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature