Improved multi-level protein-protein interaction prediction with semantic-based regularization.

ABSTRACT:

Background

Protein-protein interactions can be seen as a hierarchical process occurring at three related levels: proteins bind by means of specific domains, which in turn form interfaces through patches of residues. Detailed knowledge about which domains and residues are involved in a given interaction has extensive applications to biology, including better understanding of the binding process and more efficient drug/enzyme design. Alas, most current interaction prediction methods do not identify which parts of a protein actually instantiate an interaction. Furthermore, they also fail to leverage the hierarchical nature of the problem, ignoring otherwise useful information available at the lower levels; when they do, they do not generate predictions that are guaranteed to be consis

SUBMITTER: Sacca C 

PROVIDER: S-EPMC4004462 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature