Alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.

ABSTRACT:

Background

Elevated baseline circulating alanine aminotransferase (ALT) level has been demonstrated to be associated with an increased risk of the metabolic syndrome (MetS), but the nature of the dose-response relationship is uncertain.

Methods

We performed a systematic review and meta-analysis of published prospective cohort studies to characterize in detail the nature of the dose-response relationship between baseline ALT level and risk of incident MetS in the general population. Relevant studies were identified in a literature search of MEDLINE, EMBASE, and Web of Science up to December 2013. Prospective studies in which investigators reported relative risks (RRs) of MetS for 3 or more categories of ALT levels were eligible. A potential nonlinear relationship between ALT

SUBMITTER: Kunutsor SK 

PROVIDER: S-EPMC4004562 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature