Toll-like receptor genetic variants and colorectal cancer.

ABSTRACT: Single-nucleotide polymorphisms in Toll-like receptor 5 (TLR5), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a link between TLRs and CRC that may have both therapeutic and prognostic/predictive implications.

SUBMITTER: Weber AN 

PROVIDER: S-EPMC4004619 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature