Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy.

ABSTRACT:

Objective

The objective of this study is to estimate life expectancies of HIV-positive patients conditional on response to antiretroviral therapy (ART).

Methods

Patients aged more than 20 years who started ART during 2000-2010 (excluding IDU) in HIV clinics contributing to the UK CHIC Study were followed for mortality until 2012. We determined the latest CD4 cell count and viral load before ART and in each of years 1-5 of ART. For each duration of ART, life tables based on estimated mortality rates by sex, age, latest CD4 cell count and viral suppression (HIV-1 RNA <400 copies/ml), were used to estimate expected age at death for ages 20-85 years.

Results

Of 21 388 patients who started ART, 961 (4.5%) died during 110 697 person-years. At start of ART, expected age at d

SUBMITTER: May MT 

PROVIDER: S-EPMC4004637 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature