Invasive adenocarcinoma of the lung is associated with the upper lung regions.

ABSTRACT:

Objectives

We postulated that ventilation-perfusion (V/Q) relationships within the lung might influence where lung cancer occurs. To address this hypothesis we evaluated the location of lung adenocarcinoma, by both tumor lobe and superior-inferior regional distribution, and associated variables such as emphysema.

Materials and methods

One hundred fifty-nine cases of invasive adenocarcinoma and adenocarcinoma with lepidic features were visually evaluated to identify lobar or regional tumor location. Regions were determined by automated division of the lungs into three equal volumes: (upper region, middle region, or lower region). Automated densitometry was used to measure radiographic emphysema.

Results

The majority of invasive adenocarcinomas occurred in the upper lob

SUBMITTER: Kinsey CM 

PROVIDER: S-EPMC4004700 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature