Research resource: EPSLiM: ensemble predictor for short linear motifs in nuclear hormone receptors.

ABSTRACT: Nuclear receptors (NRs) are a superfamily of transcription factors central to regulating many biological processes, including cell growth, death, metabolism, and immune responses. NR-mediated gene expression can be modulated by coactivators and corepressors through direct physical interaction or protein complexes with functional domains in NRs. One class of these domains includes short linear motifs (SLiMs), which facilitate protein-protein interactions, phosphorylation, and ligand binding primarily in the intrinsically disordered regions (IDRs) of proteins. Across all proteins, the number of known SLiMs is limited due to the difficulty in studying IDRs experimentally. Computational tools provide a systematic and data-driven approach for predicting functional motifs that can be used to pri

SUBMITTER: Xue R 

PROVIDER: S-EPMC4004780 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature