Impact of cancer therapies on ovarian reserve.

ABSTRACT:

Objective

To determine whether measures of ovarian reserve differ between females exposed to cancer therapies in a dose-dependent manner as compared with healthy controls of similar age and late reproductive age.

Design

Cross-sectional analysis of data from a prospective cohort study.

Setting

University medical center.

Patient(s)

Seventy-one cancer survivors aged 15-39 years; 67 healthy, similarly aged unexposed subjects; and 69 regularly menstruating women of late reproductive age (40-52 years).

Intervention(s)

None.

Main outcome measure(s)

Early follicular-phase hormones (FSH, E(2), inhibin B, antimüllerian hormone [AMH]) and ovarian ultrasound measurements (ovarian volume and antral follicle counts [AFC]) were compared using multivariable linea

SUBMITTER: Gracia CR 

PROVIDER: S-EPMC4005036 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature