Persistent cellular metabolic changes after hemithyroidectomy for benign euthyroid goiter.

ABSTRACT:

Background

The significance of perturbations of thyroid-stimulating hormone (TSH) and thyroid hormones within the laboratory reference ranges after hemithyroidectomy is unknown. Our aim was to examine changes in TSH and thyroid hormones after hemithyroidectomy for benign euthyroid goiter, focusing on tissue response by examining the mitochondrial membrane potential (MMP) of peripheral blood mononuclear cells (PBMCs) and basal oxygen consumption (V˙O2).

Materials and methods

In a prospective study on 28 patients and controls, we examined serum TSH and thyroid hormones before hemithyroidectomy and 1, 3, 6 and 12 months after hemithyroidectomy for benign euthyroid goiter. In the hemithyroidectomy group, flow cytometry was used to measure the MMP of tetramethylrhodamine methyl e

SUBMITTER: Toft Kristensen T 

PROVIDER: S-EPMC4005256 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature