Targeting angiogenesis for the treatment of prostate cancer.

ABSTRACT:

Introduction

While multiple therapies exist that prolong the lives of men with advanced prostate cancer, none are curative. This had led to a search to uncover novel targets for prostate cancer therapy, distinct from those of traditional hormonal approaches, chemotherapies, immunotherapies and bone-targeting approaches. The process of tumor angiogenesis is one target that is being exploited for therapeutic gain.

Areas covered

The most promising anti-angiogenic approaches for treatment of prostate cancer, focusing on clinical development of selected agents. These include VEGF-directed therapies, tyrosine kinase inhibitors, tumor-vascular disrupting agents, immunomodulatory drugs and miscellaneous anti-angiogenic agents. While none of these drugs have yet entered the market fo

SUBMITTER: Antonarakis ES 

PROVIDER: S-EPMC4005337 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature