An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins.

ABSTRACT: Cys(2)-His(2) zinc finger proteins (ZFPs) are the largest family of transcription factors in higher metazoans. They also represent the most diverse family with regards to the composition of their recognition sequences. Although there are a number of ZFPs with characterized DNA-binding preferences, the specificity of the vast majority of ZFPs is unknown and cannot be directly inferred by homology due to the diversity of recognition residues present within individual fingers. Given the large number of unique zinc fingers and assemblies present across eukaryotes, a comprehensive predictive recognition model that could accurately estimate the DNA-binding specificity of any ZFP based on its amino acid sequence would have great utility. Toward this goal, we have used the DNA-binding specificitie

SUBMITTER: Gupta A 

PROVIDER: S-EPMC4005693 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature