Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses.
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ABSTRACT:
SUBMITTER: Krumm B
PROVIDER: S-EPMC4005705 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses.
Krumm Brian B Xiang Yan Y Deng Junpeng J
Protein science : a publication of the Protein Society 20140304 5
Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regul ...[more]
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