INO80-dependent regression of ecdysone-induced transcriptional responses regulates developmental timing in Drosophila.

ABSTRACT: Sequential pulses of the steroid hormone ecdysone regulate the major developmental transitions in Drosophila, and the duration of each developmental stage is determined by the length of time between ecdysone pulses. Ecdysone regulates biological responses by directly initiating target gene transcription. In turn, these transcriptional responses are known to be self-limiting, with mechanisms in place to ensure regression of hormone-dependent transcription. However, the biological significance of these transcriptional repression mechanisms remains unclear. Here we show that the chromatin remodeling protein INO80 facilitates transcriptional repression of ecdysone-regulated genes during prepupal development. In ino80 mutant animals, inefficient repression of transcriptional responses to the la

SUBMITTER: Neuman SD 

PROVIDER: S-EPMC4005881 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature