Effect of Helicobacter pylori infection on symptoms of gastroenteritis due to enteropathogenic Escherichia coli in adults.

ABSTRACT:

Background

Helicobacter pylori can cause hypochlorhydria in some hosts and predispose to diarrheal infections.

Aims

We tested the hypothesis that chronic H. pylori infection increases the risk of diarrheal illness due to an acid-sensitive organism: enteropathogenic Escherichia coli (EPEC).

Methods

After testing healthy adult volunteers for H. pylori, 19 infected and 26 uninfected subjects had gastric pH probes placed and were given 5-10 × 10(9) EPEC organisms; six had previously received a proton pump inhibitor. We measured diarrhea and created a composite gastroenteritis severity score based on symptoms in the 48 h following exposure. Outcomes were compared using logistic regression and analysis of covariance.

Results

More H. pylori-infected (36.8%) than H. py

SUBMITTER: Chang AH 

PROVIDER: S-EPMC4005911 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature