Hepatitis B splice-generated protein antibodies in Syrian chronic hepatitis B patients: incidence and significance.

ABSTRACT:

Background

Previous studies have suggested hepatitis B splice-generated protein (HBSP), when expressed, is involved in the pathogenesis of HBV infection.

Objectives

We aimed to evaluate anti-HBSP incidence and association with several HBV infection parameters in a group of Syrian chronic hepatitis B patients.

Patients and methods

Eighty treatment-naïve HBsAg-positive adult chronic hepatitis B patients' sera were included in our prospective targeted study. Liver function, virological and histological tests results were obtained from patients' medical files. Three variants of a 20-mer HBSP-derived peptide were designed based on HBV genome sequences obtained from Syrian patients' sera (GenBank Accession No. JN257148-JN257217). Microtiter plate wells were coated with the

SUBMITTER: Al-Hanafi N 

PROVIDER: S-EPMC4006098 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature