A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure.

ABSTRACT: The mapping between biological genotypes and phenotypes is central to the study of biological evolution. Here, we introduce a rich, intuitive and biologically realistic genotype-phenotype (GP) map that serves as a model of self-assembling biological structures, such as protein complexes, and remains computationally and analytically tractable. Our GP map arises naturally from the self-assembly of polyomino structures on a two-dimensional lattice and exhibits a number of properties: redundancy (genotypes vastly outnumber phenotypes), phenotype bias (genotypic redundancy varies greatly between phenotypes), genotype component disconnectivity (phenotypes consist of disconnected mutational networks) and shape space covering (most phenotypes can be reached in a small number of mutations). We also

SUBMITTER: Greenbury SF 

PROVIDER: S-EPMC4006268 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature