Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes.

ABSTRACT:

Aims/hypothesis

Short and long sleep duration are associated with increased risk of type 2 diabetes. We aimed to investigate whether genetic variants for fasting glucose or type 2 diabetes associate with short or long sleep duration and whether sleep duration modifies the association of genetic variants with these traits.

Methods

We examined the cross-sectional relationship between self-reported habitual sleep duration and prevalence of type 2 diabetes in individuals of European descent participating in five studies included in the Candidate Gene Association Resource (CARe), totalling 1,474 cases and 8,323 controls. We tested for association of 16 fasting glucose-associated variants, 27 type 2 diabetes-associated variants and aggregate genetic risk scores with continuous and

SUBMITTER: Tare A 

PROVIDER: S-EPMC4006271 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature