Connectivity underlying emotion conflict regulation in older adults with 5-HTTLPR short allele: a preliminary investigation.

ABSTRACT:

Objective

The serotonin transporter polymorphism short (s) allele is associated with heightened emotional reactivity and reduced emotion regulation, which increases vulnerability to depression and anxiety disorders. We investigated behavioral and neural markers of emotion regulation in community-dwelling older adults, contrasting s allele carriers and long allele homozygotes.

Methods

Participants (N = 26) completed a face-word emotion conflict task during functional magnetic resonance imaging, in which facilitated regulation of emotion conflict was observed on face-word incongruent trials following another incongruent trial (i.e., emotional conflict adaptation).

Results

There were no differences between genetic groups in behavioral task performance or neural activatio

SUBMITTER: Waring JD 

PROVIDER: S-EPMC4006319 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature