Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study.

ABSTRACT:

Background

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a severe but treatable autoimmune disorder which diagnosis depends on sensitive and specific antibody testing. We aimed to assess the sensitivity and specificity of serum and CSF antibody testing in patients with anti-NMDA receptor encephalitis, and the relation between titres, relapses, outcome, and epitope repertoire.

Methods

In this observational study, we used rat brain immunohistochemistry and cell-based assays (CBA) with fixed or live NMDA receptor-expressing cells to determine the sensitivity and specificity of antibody testing in paired serum and CSF samples. Samples were obtained at diagnosis from patients with anti-NMDA receptor encephalitis and from control participants worldwide. We deemed a pat

SUBMITTER: Gresa-Arribas N 

PROVIDER: S-EPMC4006368 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature