Pain in Parkinson's disease associated with COMT gene polymorphisms.

ABSTRACT:

Background

PD patients present high incidence of pain with unknown pathogenesis. Objective. We investigated the relation of COMT polymorphisms rs4633 and rs6267 with PD pain.

Subjects and methods

One hundred PD patients and 105 controls were evaluated with simplified Mc GILL pain scale and VAS scale. PD patients were assessed with H&Y grade, UPDRS score, and HAMD scale. Polymorphisms rs4633 and rs6267 were detected by PCR and direct sequencing.

Results

Fifty-seven percent of PD patients experienced pain, consisting of PD-related pain (64.91%) (the majority was dystonia pain) and non-PD-related pain (35.09%) (psychogenic pain was most frequent). The frequency of rs6267 genotype "GT/TT" and allele "T" was higher in PD pain. No difference was observed in frequencies of r

SUBMITTER: Li W 

PROVIDER: S-EPMC4006622 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature