A genomics-based classification of human lung tumors.

ABSTRACT: We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically relevant subtypes. More than 55% of all cases had at least one oncogenic genome alteration potentially amenable to specific therapeutic intervention, including several personalized treatment approaches that are already in clinical evaluation. Marked differences in the pattern of genomic alterations existed between and within histological subtypes, thus challenging the original histomorphological diagnosis. Immunohistochemical studies confirmed many of these reassigned subtypes. The reassignment eliminated almost all cases of large cell carcinomas, some of which had therapeutically relevant alterations. Prospective testing of our genomics-

SUBMITTER: Clinical Lung Cancer Genome Project (CLCGP) 

PROVIDER: S-EPMC4006630 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature