ModuleRole: a tool for modulization, role determination and visualization in protein-protein interaction networks.

ABSTRACT:

Unlabelled

Rapidly increasing amounts of (physical and genetic) protein-protein interaction (PPI) data are produced by various high-throughput techniques, and interpretation of these data remains a major challenge. In order to gain insight into the organization and structure of the resultant large complex networks formed by interacting molecules, using simulated annealing, a method based on the node connectivity, we developed ModuleRole, a user-friendly web server tool which finds modules in PPI network and defines the roles for every node, and produces files for visualization in Cytoscape and Pajek. For given proteins, it analyzes the PPI network from BioGRID database, finds and visualizes the modules these proteins form, and then defines the role every node plays in this network,

SUBMITTER: Li G 

PROVIDER: S-EPMC4006751 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature