Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies.

ABSTRACT:

Background and purpose

Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggregate effect on risk is uncertain. We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts.

Methods

Three thousand five hundred forty-eight clinic-based IS cases and 6399 controls from the Wellcome Trust Case Control Consortium 2 were used for derivation of the GRS. Subjects from the METASTROKE consortium served as a replication sample. The validation sample consisted of 22 751 participants from the Cohorts for Heart and Aging Research in Genom

SUBMITTER: Malik R 

PROVIDER: S-EPMC4006951 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature