Distant functional connectivity for bimanual finger coordination declines with aging: an fMRI and SEM exploration.

ABSTRACT: Although bimanual finger coordination is known to decline with aging, it still remains unclear how exactly the neural substrates underlying the coordination differ between young and elderly adults. The present study focused on: (1) characterization of the functional connectivity within the motor association cortex which is required for successful bimanual finger coordination, and (2) to elucidate upon its age-related decline. To address these objectives, we utilized functional magnetic resonance imaging (fMRI) in combination with structural equation modeling (SEM). This allowed us to compare functional connectivity models between young and elderly age groups during a visually guided bimanual finger movement task using both stable in-phase and complex anti-phase modes. Our SEM exploration o

SUBMITTER: Kiyama S 

PROVIDER: S-EPMC4007017 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature