Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice.

ABSTRACT:

Background

Fat inflammation may play an important role in comorbidities associated with obesity such as atherosclerosis.

Methods and results

To first establish feasibility of fat transplantation, epididymal fat pads were harvested from wild-type C57BL/6J mice and transplanted into leptin-deficient (Lep(ob/ob)) mice. Fat transplantation produced physiological leptin levels and prevented obesity and infertility in Lep(ob/ob) mice. However, the transplanted fat depots were associated with chronically increased macrophage infiltration with characteristics identical to those observed in fat harvested from obese animals. The inflammation in transplanted adipose depots was regulated by the same factors that have been implicated in endogenous fat inflammation such as monocyte chemoa

SUBMITTER: Ohman MK 

PROVIDER: S-EPMC4007137 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature